Advanced semen analysis

Advanced semen analysis : One of the main reasons for infertility in couples - in up to 50% of cases - is male infertility. Male infertility is not necessarily related to male health, as a healthy man can produce poor quality sperm that make conception difficult.

Advanced Semen Analysis in Bangalore

It is therefore very important to perform a semen analysis to determine the fertility potential of the man. A normal semen analysis or seminogram looks at the concentration, motility and morphology of the sperm cells in a semen sample.

While these factors are important in assessing basic sperm quality, there are other components that are far more important in determining the capacity of the sperm to create pregnancy. These other factors can give patients a better insight into the diagnosis and thus a more appropriate treatment plan. These evaluations are categorized as Advanced Semen Analysis.

In the Joshi's Andrology & Urology Centre laboratory, it is possible to perform an advanced Semen analysis.

Advanced semen analysis: DNA fragmentation index test for sperm.

The presence of fragmented DNA in the nucleus of sperm cells has a negative impact on reproductive results. The sperm DNA fragmentation test measures the stability of the chromatin and estimate the percentage of sperm cells that have fragmented DNA.

Any couple doing an assisted reproductive treatment can take the DNA fragmentation test for sperm. This test is especially recommended for men over 35 years of age, history of recurrent miscarriages, history of failed IVF and IUI, history of exposure to gonadotoxins, who have a genitourinary infection or who have received cancer treatment etc..

The DNA fragmentation test can be useful for couples who have had multiple miscarriages, unsuccessfully completed multiple cycles, or who cannot find a reason for their infertility.

·         Advanced semen analysis: Apoptosis -Annexin V test

Apoptosis or cell death plays an important role in spermatogenesis by eliminating sperm cells with structural or functional defects. The presence of an abnormally high level of dead sperm in the ejaculate can adversely affect male fertility.

The Apoptosis -Annexin V test determines the number of damaged sperm cells in the ejaculate and / or the sperm samples reserved for assisted reproduction. The assay uses the Annexin V protein to mark the damaged cells, which are then counted. The quality of samples with abnormally high apoptosis can be improved by specifically removing damaged sperm cells, using the Annexin V MACS Technique.

·         Advanced semen analysis: Oxidative Stress test (ROS)

The sperm cells produce small amounts of reactive oxygen species (ROS, short for reactive oxygen species) that are essential for their normal functioning. This amount of ROS is controlled by the antioxidants present in the fluid from the prostate and seminal vesicles.

However, as the balance between reactive oxygen component production and antioxidant activity shifts, ROS levels will increase. This causes oxidative stress, which damages the sperm and decreases fertility. Increasing the levels of ROS can be reduced through lifestyle changes and a diet rich in antioxidants.

 

·         Advanced Sperm Analysis: Y Chromosome Microdeletion Test

The microdeletions in the AZF factor of the Y chromosome are responsible for about 10-15% of azoospermia and 5-10% of oligospermia cases in men. The Y chromosome microdeletion test examines parts of the Y chromosome by PCR: AZFa, AZFb, AZFc. This identifies possible causes of male infertility.

 

 

Joshi's Andrology & Urology Centre

Address: Neelamma Complex, Opposite Unlimited mall, No 44/2 1st floor, 60 Feet Rd, G Block, Sahakar Nagar, Bengaluru, Karnataka 560092

Appointments: https://joshiuroandrology.com/Pages/Contact-Us, 

Phone: 080 4207 0577

Reduced fertility in men | Male infertility treatment in Bangalore

Reduced fertility in men| Male infertility treatment in Bangalore 

Fertility disorder is on the rise and about 35- 40% of cases male factors may be the cause. Many factors influence male fertility. Often these are due to abnormalities in the sperm cells.

Male infertility treatment in Bangalore

Causes

Fertility problems in men are often related to abnormalities in the sperm cells. These are related to disorders in:

• Production of sperm cells
• Transport of sperm cells
• Hormones that stimulate sperm production

Nevertheless, it is important to realize that in at least half of the cases a good medical explanation cannot be found for reduced fertility in men.

Production of sperm cells

Problems in the production of sperm cells can lead to a reduced number, reduced mobility or an abnormal shape of the sperm cells.

Numerous factors can cause this:

• ·         Infection or inflammation of the testes
• ·         Twisting (torsion) of the testes, cutting off blood flow to the testes
• ·         Undescended testes or other abnormal positions
• ·         Genetic abnormalities
• ·         Damaged secretions between seminal ducts and blood vessels
• ·         Medicines that (sometimes temporarily) reduce fertility (e.g. anabolic steroids)
• ·         Chemotherapy and radiation
• ·         Pesticides and chemicals
• ·         Transport of sperm cells

If the sperm cells are of good quality, they still have to get to the egg. Sperm transport disorder is another cause of reduced fertility in men.

Possible reasons for a disturbance in transport:

Erectile dysfunction, in which the penis is not rigid enough or is not rigid long enough for normal sexual intercourse.

Premature ejaculation, where the semen is ejaculated very early may not be introduced into the vagina.

Retrograde ejaculation, where the semen enters the male's bladder. Some of the causes for this are diabetes and prior surgeries on bladder neck.

Obstruction of the sperm ducts, so that there are no sperm cells in the ejaculate (eg with cystic fibrosis or after sterilization)

Hormones that stimulate sperm production

Sometimes the body does not make enough hormones that stimulate sperm production.

Such a disorder therefore leads to reduced fertility in men.

Investigations and diagnosis

In a suspected case, we may have to perform a few tests.

Semen Analysis

Blood test for male fertility problems

Male blood tests that screen for infectious diseases, genetic abnormalities and other factors that can lead to reduced fertility. The blood test is a standard test for fertility problems.

Examination of the quality of sperm cells and the amount of sperm cells.

Andrological examination

Consultation with the Uro-andrologist Dr. Praveen Joshi, who examines the male reproductive organs.

Scrotal scan may have to be done in some of the cases in order to evaluate the testicular conditions and other details like varicocele.

Therapy

Here are some possible treatments for this condition. After the diagnosis, your doctor, together with you and the other doctors on the team, will choose the best solution for you. Your Male infertility treatment may need a team effort.

Lifestyle modification

Varicocele correction by microsurgical procedure

Testicle aspiration, biopsy, microsurgical procedures for sperm retrieval in cases of azoospermia (Sperm count is zero). This type of sample can be stored. The frozen material can later be used for fertilitytreatment.

Hormonal treatment

Hormonal or drug treatment for hormonal disorders.

We, Joshi’s Andrology and Urology Centre have more 10 years of experience in treating men with various fertility problems. In fact, it has become an important specialty. We see positive results in many patients. We don’t give up on any of our patient no matter how bad the condition might appear.

Make an appointment

Would you like an appointment or would you like to meet? Call 080 – 42070577, +918197371247 or Submit your e-mail address or telephone number on Website Enquiry page Male infertility treatment in Bangalore, and we will email or call you when it suits you.