Advanced semen analysis : One of the main reasons for infertility in couples - in up to 50% of cases - is male infertility. Male infertility is not necessarily related to male health, as a healthy man can produce poor quality sperm that make conception difficult.
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| Advanced Semen Analysis in Bangalore |
It is therefore very important to perform a semen analysis to
determine the fertility potential of the man. A normal semen analysis or
seminogram looks at the concentration, motility and morphology of the sperm
cells in a semen sample.
While these factors are important in assessing basic sperm
quality, there are other components that are far more important in determining
the capacity of the sperm to create pregnancy. These other factors can give
patients a better insight into the diagnosis and thus a more appropriate
treatment plan. These evaluations are categorized as Advanced Semen Analysis.
In the Joshi's
Andrology & Urology Centre laboratory, it is possible to perform an
advanced Semen analysis.
Advanced semen analysis: DNA fragmentation index test for
sperm.
The presence of fragmented DNA in the nucleus of
sperm cells has a negative impact on reproductive results. The sperm DNA
fragmentation test measures the stability of the chromatin and estimate the
percentage of sperm cells that have fragmented DNA.
Any couple doing an assisted reproductive
treatment can take the DNA fragmentation test for sperm. This test is
especially recommended for men over 35 years of age, history of recurrent
miscarriages, history of failed IVF and IUI, history of exposure to gonadotoxins,
who have a genitourinary infection or who have received cancer treatment etc..
The DNA fragmentation test can be useful for couples who
have had multiple miscarriages, unsuccessfully completed multiple cycles, or
who cannot find a reason for their infertility.
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Advanced semen analysis: Apoptosis -Annexin V
test
Apoptosis or cell death plays an important role in
spermatogenesis by eliminating sperm cells with structural or functional
defects. The presence of an abnormally high level of dead sperm in the ejaculate
can adversely affect male fertility.
The Apoptosis -Annexin V test determines the number of
damaged sperm cells in the ejaculate and / or the sperm samples reserved for
assisted reproduction. The assay uses the Annexin V protein to mark the
damaged cells, which are then counted. The quality of samples with abnormally
high apoptosis can be improved by specifically removing damaged sperm cells,
using the Annexin V MACS Technique.
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Advanced semen analysis: Oxidative Stress
test (ROS)
The sperm cells produce small amounts of reactive oxygen
species (ROS, short for reactive oxygen species) that are essential for their
normal functioning. This amount of ROS is controlled by the antioxidants
present in the fluid from the prostate and seminal vesicles.
However, as the balance between reactive oxygen component
production and antioxidant activity shifts, ROS levels will increase. This
causes oxidative stress, which damages the sperm and decreases fertility. Increasing
the levels of ROS can be reduced through lifestyle changes and a diet rich in
antioxidants.
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Advanced Sperm Analysis: Y Chromosome
Microdeletion Test
The microdeletions in the AZF factor of the Y chromosome are
responsible for about 10-15% of azoospermia and 5-10% of oligospermia cases in
men. The Y chromosome microdeletion test examines parts of the Y chromosome by
PCR: AZFa, AZFb, AZFc. This identifies possible causes of male infertility.
Joshi's Andrology &
Urology Centre
Address: Neelamma Complex,
Opposite Unlimited mall, No 44/2 1st floor, 60 Feet Rd, G Block, Sahakar Nagar,
Bengaluru, Karnataka 560092
Appointments: https://joshiuroandrology.com/Pages/Contact-Us,
Phone: 080 4207 0577
